Wersja polska

 

Location

Faculties

Technicians

Research

Scientific cooperation

 

 

Location

 

  • The medical laboratory is located at Rzeszów District Hospital at 2 Chopin Street, Rzeszów
  • Immunological laboratory: 107
  • Student’s laboratories (building H): 107, 61, 8
  • Office of the Head of Department (H): 144
  • Other rooms (H): 104 A, 104 B, 58.
  • Elementary analytical laboratory: 218

 

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Faculties

 

  • Elżbieta Wałajtys-Rode; Professor, Head of Department, room 144,

 phone: (48)(17)8651927; E-mail: ewalajty@prz.rzeszow.pl;

  • Andrzej Skręt; Professor, address: 2 Chopin Street, Rzeszów, phone: (48) (17) 8666252;
  • Stanisław Wołowiec, Dr Sci., room 104 A, phone (48) (17) 8651657, E-mail: sw@prz.rzeszow.pl;
  • Maria Czygier, room 144, phone: (48)(17)8651927; E-mail: mczygier@prz.rzeszow.pl
  • Tomasz Ruman, Ph.D., room 104 A, phone (48) (17) 8651657
  • Magdalena Zaręba, M. Sci., Eng., room 104 B, phone (48) (17) 8651657

 

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Technicians

 

·        Bożena Sanecka; B. Sc., Eng., room 104 B; phone: (48) (17) 8651896, (48) (17) 8651924 (Elementary Analytical Laboratory) E-mail: sanecka@prz.rzeszow.pl

·        Małgorzata Semik; B. Sc. Room 58; phone: (48) (17) 8651897

·        Tadeusz Więcek; B. Sc., Eng., room 85, phone (48) (17) 8651695, E-mail: tawiecek@prz.rzeszow.pl

 

 

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Research projects and teams (photo page)

 

I.

Nitric oxide production during various pathological conditions in human (possible diagnostic applications)

Prof. E. Wałajtys-Rode and M. Czygier

(Grant KBN 4P05A 02612)

Recent papers

1. V. Saczyńska, A. Porębska, A. Słotwiński, M. Czygier, E. Wałajtys-Rode, “Pre- and post- operative nitric oxide production by neutrophils from  blood of patients with gastrointestinal and liver cancer”

 

Proceedings of EFIS 2000, Ed. A. Mackiewicz, M. Kurpisz, J. Żeromski , Monduzzi Editore Int. Proc. Div. (2000) 1-6.

2. J.M. Dzik, A. Dobrzańska, D. Gruszfeld, E. Wałajtys-Rode

“Nitric oxide metabolites in urine of term and preterm infants”

Pediatrics Int. 44 (2002) 368-375.

 

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II.

 Investigations of the role of alveolar macrophages in innate defence mechanisms against parasitic nematodes (Toll-like receptors, NO and signal transduction pathways)

Prof. E. Wałajtys-Rode

(Grant KBN nr 4PO5F 02414, principial investigator)

Recent papers

1. M. J. Dzik, Z. Zieliński, B. Gołos, E. Jagielska, M. Wranicz, E. Wałajtys-Rode

„Effect of cyclosporin A on immunological response in lungs of guinea pigs infected with Trichinella spiralis

Acta Biochim. Pol. 49 (2002) 233-247.

 

2. J. M. Dzik, B Golos, E. Jagielska, A. Kapała, E. Wałajtys-Rode (2002)

“Early response of guinea-pig lungs to Trichinella spiralis infection”

Parasite Immunol. 24 (2002) 369-379.

 

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III.

 Production of monoclonal antibodies against weak immunogens

Prof. E. Wałajtys-Rode

Recent papers:

1. M. Wenke, A. Porębska, E. Wałajtys-Rode  (2001) „Uzyskanie przeciwciał monoklonalnych  przeciwko izoprenoidom”

Biotechnologia 3 (2001)169-177.

 

2. E. Wałajtys-Rode E.

„Renesans przeciwciał”

Biotechnologia, 3 (2001) 29-36.

 

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IV.

Production of monoclonal antibodies (Mab) against native and recombinant thymidylate synthase (TS) from various species (rat, mouse, human, T. spiralis, C. elegans) and its application for studies of the mechanisms of TS action, localization of TS in situ, and early diagnosis of cancer.

Prof. E. Wałajtys-Rode

(Grant KBN nr 6PO4C 02118  - principial investigator, Grant KBN nr 4PO5F 02618 - investigator, Grant KBN nr 6PO4C 00321 - investigator)

Recent papers

1. B. Gołos, E. Wałajtys-Rode, A. Porębska, J. Cieśla, M. Dądrowska, Z Zieliński, W. Rode (2001)

“Thymidylate synthase heterogeneity assessed by monoclonal antibodies”

in “Chemistry and Biology of Pteridines and Foliates” Eds.: S. Milstein, G. Kapatos, R. A. Levine, B. Shane (2001) 519-523, Kluwier Academic Publishers, Boston, London.

 

2. J. Cieśla, B. Gołos, E. Wałajtys-Rode, E. Jagielska, A. Płucienniczak, W. Rode

“The effect of Arg209 to Lys mutation in mouse thymidylate synthase”

Acta Biochem. Pol. 3 (2002) 651-658.

 

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V.

Investigations of calcium homeostasis in mitochondria.

Prof. E. Wałąjtys-Rode

Recent papers

1. E. Wałajtys-Rode, G. Moehren, J.B. Hoek

“Effect of protein tyrosine kinases on mitochondrial calcium homeostasis in rat hepatocytes treated with thapsigargin”

Cell. Mol. Biol. Lett. 3 (1998) 344-346.

 

2. J. B. Hoek, E. Walajtys-Rode, A. M.  Diehl

“Mitochondrial uncoupling associated with expression of uncoupling protein-2 in hepatocytes from genetically obese ob ob mice” 

Biophys J. 76 (1999) A239-A239 Part 2.

 

3. K. D. Chavin, S. Q. Yang, H. Z. Lin, J. Chatham, V. P. Chacko, J. B. Hoek, E. Walajtys-Rode, A. Rashid, C. H. Chen, C. C. Huang, T. C. Wu, M. D. Lane, A. M. Diehl

“Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion”

J. Biol. Chem. 247 (1999) 5692-5700.

 

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VI.

 DNA analysis in medical diagnosis

Prof. A. Skręt + coworkers from Rzeszów District Hospital

 

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VII.

Interaction of transition metal ion complexes with nucleic acids

Dr. S. Wołowiec, E. Wałajtys-Rode, M. Czygier, A. Nieradka (undergraduate student)

Projects starts at fall semester 2003/2004

 

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VIII.

Artificial endonucleases

Dr. S. Wołowiec,

E. Wałajtys-Rode, A. Skręt, M. Czygier, , B. Sanecka, M. Semik, A. Nieradka (undergraduate student)

Projects starts at fall semester 2003/2004

 

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IX.

Mono- and polynuclear transition metal ion complexes as catalysts for induction of asymmetry

Dr. S. Wołowiec,

M. Zaręba, J. Kisała (Ph.D. student from Wrocław University), T. Ruman (Ph.D.), M. Legięć (undergraduate student).

Recent papers

1. M. Zaręba, Z. Ciunik, K. Drabent, S. Wołowiec

„Substituted Pyrazole as Bridging and Terminal Ligand for Transition Metal Ions”

Inorg. Chem. Commun., in press.

 

2. Z. Ciunik, J. A. Wolny, M. F. Rudolf, S. Wolowiec
"cis-trans isomerism and rotational isomerism in triazene-1-oxide bis-chelates of palladium(II)"
J. Chem. Soc., Dalton Trans. (2002) 885-895.

 

3. M. Łukasiewicz, Z. Ciunik, J. Mazurek, J. Sobczak, A. Staroń, S. Wołowiec, J. J. Ziółkowski, „X-ray structure, magnetic and catalytic properties of a cyclic trinuclear Co(II)/Co(III)/Co(III) complex with m3-hydroxy anion”
Eur. J. Inorg. Chem. (2001) 1575-1579.

 

4. Z. Olejnik, T. Lis, A. Vogt, S. Wołowiec, J. Skarżewski,
”Single crystal-to-single crystal Transformation of the Dichloromethane Solvate of the Schiff Base Manganese(III) Complex to a Solvent Free Material”
J. Inclus.
Phen. Macromol. Chem. 38 (2000) 221-232.

 

5. E. Kwaskowska-Chęć, J. J. Ziółkowski, M. Moszner, S. Wołowiec,

“Neutral and Cationic Complexes of Rh(I) with the Tridentate Bis(benzimidazole)amine Ligands”

J.Chem.Res. (S) (1999) 642-643.

 

6. R. Blauw, I. E. Kingma, W. L. J. Werner, S. Wołowiec, J. L. van der Baan, S. Balt, F. Bickelhaupt, M. W. G. de Bolster, G. W. Klumpp
"Intramolecularly Alkylated Salen Complexes: Thermolysis and Photolysis of Coenzyme B12 Models with a Cobalt-to-Ligand Carbon Bridge"
Inorg. Chim. Acta, 269 (1998) 203-210.

 

7. A. Vogt, R. L. Prasad, A. Gupta, J. Skarżewski, S. Wołowiec,
"Synthesis and Characterization of Nickel(II), Copper(II), Manganese(III), and Iron(III) Complexes with New Chiral Salen-type Ligand"
Polyhedron, 17 (1998) 1231-1240.

 

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X.

 Transition metal ion complexes with tripodal ligands

Dr. S. Wołowiec

J. Kisała (Ph.D. student from Wrocław University), T. Ruman (Ph.D.), M. Legięć (undergraduate student).

The project is financed by Polish Committee for Scientific Research (KBN) Grant 3T09A 05219 (years 2000-2003)

Recent papers

1. T. Ruman, Z. Ciunik, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate ligands.

Part XII. Variable hapticity of hydrobis(3-phenyl-5-isopropylpyrazolyl)(3,5-dimethylpyrazolyl)borate in its rhodium(I) complexes with COD and NBD”

Polyhedron, 23/2-3 (2004) 219-223

 

2. Z. Ciunik, T. Ruman, M. Łukasiewicz, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate ligands. Part XI.

Weak CH/p interactions in crystals of hydrotris(3-phenylpyrazolyl)boratothallium(I) and hydrobis(5-methyl-3-phenylpyrazolyl)(3,5-dimethylpyrazol-yl)boratothallium(I) studied by X-ray crystallography”

J. Mol. Struct., 690/1-3 (2004)

 

3. T. Ruman, Z. Ciunik, S. Wołowiec,

Complexes of heteroscorpionate trispyrazolylborate anionic ligands. Part VIII. Synthesis, X-ray crystallographic and 1H NMR structural studies on cobalt(II) complexes of homoscorpionate, heteroscorpionates and chiral trispyrazolylborates obtained from 3(5)-phenyl-5(3)-iso-propylpyrazole and 3,5-dimethylpyrazole”

Eur. J. Inorg. Chem. (2003) 2475-2485.

 

4. J. Kisała, Z. Ciunik, K. Drabent, T. Ruman, S. Wołowiec

“The complexes of tetra(3-isopropylpyrazolyl)borate anionic ligand with cobalt(II), nickel(II) and copper(II)”

Polyhedron 22 (2003) 1645-1652.

 

5. T. Ruman, Z. Ciunik, A. M. Trzeciak S. Wołowiec, J. J. Ziółkowski

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands. Part X.

Structures and Fluxional Behavior of Rhodium(I) Complexes with Heteroscorpionate Trispyrazolylborate Ligands, Tp”Rh(LL); (LL) = (CO)2 or (COD)’

Organometallics, 22 (2003) 1072-1080

 

6. T, Ruman, Z. Ciunik, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate ligands. Part IX. X-ray crystallographic studies on cobalt(II) complexes of hydrobis(3-phenyl,5-methylpyrazolyl)(3,5-diethylpyrazolyl)borate”

Polyhedron 22 (2003) 581-586.

 

7. T. Ruman, Z. Ciunik, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands. Part VII.

The bonding ambivalency of 3(5)-iso-propylpyrazolyl moiety in homo- and heteroscorpionate hydrobis(n-iso-propylpyrazolyl)(3-R1-5-R2-pyrazolyl)boratocobalt(II) complexes.

Eur. J. Inorg. Chem. (2003) 89-93.

 

8. T. Ruman, Z. Ciunik, E. Szklanny, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands. Part VI.

Carboxylate induced conversion of mono-ligand Tp’M(L) into bis-ligand Tp’2M complexes (M = Co(II) and Cu(II)).

Polyhedron 21 (2002) 2743-2753.

 

9. T. Ruman, Z. Ciunik,  A. Goclan, M. Łukasiewicz, S. Wołowiec

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands. Part V. X-ray crystallographic studies of cobalt(II) complexes with hydrobis(3,5-dimethylpyrazolyl)(3,5-diphenylpyrazolyl)borate and hydrobis(3,5-diphenylpyrazolyl)(3,5-dimethylpyrazolyl)borate ligands.”

Polyhedron 20 (2001) 2965-2970.

 

10. T. Ruman, Z. Ciunik, J. Mazurek, S. Wołowiec

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands.

Part IV. Poly(pyrazolyl)borate anionic ligands obtained from 3,5-dimethylpyrazole and 3,5-diphenylpyrazole and their cobalt(II) complexes.”

Eur. J. Inorg. Chem. (2002) 754-760

 

11. T. Ruman, M. Łukasiewicz, Z. Ciunik, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands.

Part III. X-ray crystallographic and NMR studies on cobalt(II) complexes with tris(pyrazolyl)borate anionic ligands obtained from 3,5-dimethylpyrazole and 3(5)-methyl,5(3)-phenylpyrazole.

Polyhedron 20 (2001) 2551-2558.

 

12. M. Łukasiewicz, Z. Ciunik, T. Ruman, M. Skóra, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands.

Part II. The X-ray crystallographic and 1H NMR studies on thiocyanato[hydrobis(3-phenylpyrazolyl)(3,5-di-tert-butylpyrazolyl)borato]cobalt(II) and thiocyanato[hydrobis(3-phenyl,5-methylpyrazolyl)(3-methyl,5-phenylylpyrazolyl)borato]cobalt(II) complexes.”

Polyhedron 20 (2001) 237-244.

 

13. M. Łukasiewicz, Z. Ciunik, S. Wołowiec,

“Complexes of heteroscorpionate trispyrazolylborate anionic ligands.

Part I. The crystal structure and reactivity of thiocyanato[hydrobis(3-phenylpyrazolyl)(3-tert-butylpyrazolyl)borato]cobalt(II) complex.“

Polyhedron 19 (2000) 2119-2125.

 

14. M. Moszner, S. Wołowiec, H. Vahrenkamp, A. Trösch,

 “Synthesis and Structure of Rh(I) Tris(pyrazolyl)borate Complexes of the Type TPPh,MeL1L2

J. Organomet. Chem. 595 (2000) 178-185.

 

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XI.

Metaloporphyrins and dimetalodiporphyrins

Dr. S. Wołowiec,

J. Borowiec (graduate student), M. Dubel (undergraduate student)

Recent papers

1. J. Borowiec, I. Trojnar, S. Wołowiec

“Dimetalodiporphyrins with flexible covalent link. Part IV. Mono- dizinc(II)diporphyrins with variable length hydrocarbon spacer attached to meso-(ortho-phenoxy) position”

Polyhedron, in press.

 

2. J. Borowiec, S. Wołowiec,

“Synteza diporfiryn z giętkim łącznikiem węglowodorowym”

Prace Kół Naukowych Politechniki Rzeszowskiej 2000/2001, 9-23.

 

3. J.-P. Simonato, J. Pécaut, L. Le Pape, J.-L. Oddou, C. Jeadney, M. Shang, W. R. Scheidt, J. Wojaczyński, S. Wołowiec, L. Latos-Grażyński, J.-C. Marchon,

“An Integrated Approach to the Mid-Spin State (S = 3/2) in Six-Coordinate Iron(III) Chiroporphyrins”

Inorg. Chem. 39 (2000) 3978-3987.

 

4. P. A. Stuzhin, M. Goeldner, H. Homborg, A. S. Semeikin, I. S. Migalova, S. Wołowiec, “Diazaporphyrins: Synthesis, Characterization and X-Ray Crystal Structure of (3,7,13,17-Tetramethyl-2,8,12,18-tetrabutyl-5,15-diazaporphinato)chloroindium(III)”

Mendeleev Commun. (1999) 134-136.

 

5. P. A. Stuzhin, O. V. Malchugina, S. Wołowiec, L. Latos-Grażyński, B. D. Berezin,

"Formation of stable -aryliron(III) complexes from the reaction of chloroiron(III) octaphenyltetraazaporphyrinate with aryl Grignard reagent"

Mendeleev Commun. (1998) 144-145.

 

6. S. Wołowiec, L. Latos-Grażyński

"Oxidation of Iron(III) Tetramesitylporphyrin  with Dimethyldioxirane"

Inorg. Chem. 37 (1998) 2984-2988.

 

7. S. Wołowiec

"2-D COSY and NOESY 1H NMR Spectral Studies on Pyrazine Bridged Dizinc(II)diporphyrin Complex"

Polyhedron 17 (1998) 1295-1301.

 

8. T. Bartczak, S. Wołowiec, and L. Latos-Grażyński

"Crystal Structure and Molecular Stereochemistry of the 1:2 Adduct of Anionic Complex, Dicyano-(5,10,15,20-tetramesityleneporphynato) iron(II) with bis(triphenyl- phosphine)nitrogen (1+), I2, CDCl3 "

Inorg. Chim. Acta. 277 (1998) 242-246.

 

9. M. Mazzanti, J.-C. Marchon, J. Wojaczyński, S. Wołowiec, L. Latos-Grażyński, M. Shang, W. R. Scheidt,

"High-spin Iron(III) Chiroporphyrins: Structural, Magnetic, and 1H NMR Studies"

Inorg. Chem. 37 (1998) 2476-2481.

 

10. S. Wołowiec,  L. Latos-Grażyński, D. Toronto, J.-C. Marchon,

"Stabilization of the Less Common (dxzdyz)4(dxy)1 Iron(III)porphyrin Ground Electronic State - 1H NMR Investigations of Iron(III) 5,10,15,20-tetra- cyclohexylporphyrin"

Inorg. Chem. 37 (1998) 724-732.

 

Scientific cooperation

 

Permanent cooperation links:

  • Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, within the projects II and IV (E. Wałajtys-Rode)
  • Institute of Biotechnology and Antibiotics, Polish Academy of Sciences, Warsaw, within the project I (E. Wałajtys-Rode)
  • Warsaw Medical University, within the project I (E. Wałajtys-Rode)
  • Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, within the project III (E. Wałajtys-Rode)
  • Wrocław University (Poland, within the projects IX and X  (S. Wołowiec)
  • Wrocław University of Technology (Poland) within the projects IX and X  (S. Wołowiec)
  • Kraków University of Technology (Poland) within the projects IX- and XI (S. Wołowiec)
  • Thomas Jeffferson University , Medical College, Philadelphia, USA, within the project V (E. Wałajtys-Rode)
  • CEA CNRS Grenoble (France) within the project XI (S. Wołowiec)
  • Vienna University of Technology (Austria) within the project X (S. Wołowiec)

 

 

 

 

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